From Paramignya trimera plants that were collected in the Hon Heo Commune (Khanh Hoa province, November 2013), n-hexane extracts of its stem bark and leaves was obtained which showed moderate cytotoxic activity towards KB, Hep-G2, Lu and MCF7 celllines (with ICso values ranging from 5.7 to 30.89 uglrnL). A GC-MS analysis of the volatile plant components showed that esters, saturated alcohols and sesquiterpenes, including, beta-farnesene and alpha-gurjunene, are the major compounds.