Assembling branched and macrocyclic peptides on proteins.

• Tác giả: Santhanalaxmi Kumaresan, Richard Morewood, Christoph Nitsche, Bishvanwesha Panda, Marina G Rahman, Sven Ullrich
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.456 *Assemblers
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 54429

Tóm tắt

A two-step, biocompatible strategy enables site-specific generation of branched and macrocyclic peptide-protein conjugates. Solvent-exposed cysteines on proteins are modified by a small bifunctional reagent at near-physiological pH, followed by cyanopyridine-aminothiol click reactions to create branched or macrocyclic peptide architectures. This method offers design strategies for next-generation protein therapeutics.