Cost-effective microfluidic flow cytometry for precise and gentle cell sorting.

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Tác giả: Lu Gan, Chunhua He, Guanglan Liao, Zhiyong Liu, Lei Nie, Tielin Shi, Jianxin Wang, Shuang Xi, Canfeng Yang, Xiangliang Yang, Tuying Yong, Huasheng Zhuo

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Lab on a chip , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 54460

Microfluidic flow cytometry (MFCM) is considered to be an effective substitute for traditional flow cytometry, because of its advantages in terms of higher integration, smaller device size, lower cost, and higher cell sorting activity. However, MFCM still faces challenges in balancing parameters such as sorting throughput, viability, sorting efficiency, and cost. Here, we demonstrate a cost-effective and high-performance microfluidic cytometry cell sorting system, along with a customized microfluidic chip that integrates hydrodynamic focusing, droplet encapsulation, and sorting for precise cell manipulation. An innovative photon incremental counting-based fluorescence detection method is proposed, which requires only one-fiftieth of the data compared to traditional methods. This significantly simplifies the structure of the system and substantially reduces costs. The system exhibits detection recoveries exceeding 95% across sample solution flow rates ranging from 10 to 80 μL min
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