Hiệu lực một số loại vacxin cúm gia cầm sử dụng trên gà chống lại virus cúm A/H5N6 clade 2.3.4.4B=Efficacy of Avian influenza vaccines testing in chicken against A/H5N6 clade 2.3.4.4B virus

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Tác giả: Nguyễn Văn Cảm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2018

Mô tả vật lý: tr.11

Bộ sưu tập: Báo, Tạp chí

ID: 544741

Thêm vào giỏ

Để đánh giá hiệu lực của một số loại vacxin chống lại virus gây bệnh cúm gia cầm A/H5N6 cườngđộc mới xuất hiện tại Việt Nam, thí nghiệm đã được tiến hành trên gà với vacxin Navet-Vifluvac sảnxuất trong nước, vacxin Re-5 và vacxin Re-6 nhập từ Trung Quốc. Kết quả xét nghiệm huyết thanhgà sau tiêm phòng bằng phương pháp HI, dùng kháng nguyên đồng chủng với kháng nguyên trongvacxin cho thấy: vacxin Navet-Vifluvac kích thích gà tạo kháng thể với hiệu giá 4,3log2
với vacxinRe-5, hiệu giá kháng thể là 7,8log2 và với vacxin Re-6, hiệu giá kháng thể là 5,3log2. Sau khi côngcường độc bằng virus A/H5N6 clade 2.3.4.4B, đã thu được kết quả như sau: vacxin Navet-Vifluvac,Re-5 và Re-6 đều có khả năng bảo hộ 70% đối với gà được tiêm phòng. Gà của tất cả 3 nhóm tiêmvacxin đều bài thải virus trong 10 ngày sau khi công cường độc, tuy nhiên nhóm gà được tiêm vacxinNavet-Vifluvac giảm bài thải virus một cách đáng kể 10 ngày sau khi công cường độc. Nhóm gà tiêmvacxin Re-5 vẫn bài thải nhiều virus sau 10 ngày công cường độcIn order to assess the efficacy of some vaccines against the newly- occurred avian influenzaA/H5N6 virus in Viet Nam, this study was conducted on the chickens with locally-made NavetVifluvac vaccine, the Re-5 vaccine and the Re-6 vaccine imported from China. The result oftesting chicken serum after vaccination using HI test with the antigen homologous with that invaccines showed that these vaccines induced the experimental chickens in antibody productionwith a titre of 4.3log2 for Navet vifluvac vaccine
7.8log2 for Re-5 vaccine and 5.3log2 for Re-6vaccine. The result of virulent challenge with A/H5N6 clade 2.3.4.4B showed that the protectiverate of the vaccinated chickens for all three vaccines Navet-Vifluvac, Re-5 and Re-6 vaccineswas 70%. The vaccinated chickens with three vaccines discharged virus within 10 days afterchallenge, but the vaccinated chickens with Navet-Vifluvac significantly reduced viral sheddingin 10 days, post-challenge. The vaccinated chickens with Re-5 vaccine excreted virus with highlevel in 10 days, post-challenge

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