Surface modification of polymer materials is crucial in the biomedical field, as it can endow materials with new properties, including high efficacy and durability and a low risk of infection. Here, we propose a simple, green, and reliable surface modification strategy using ovalbumin (OVA) and tannic acid (TA). The hydrogen bonds and hydrophobic interactions revealed between the OVA and TA molecules make the OVA/TA composite tenacious and stable. The subsequent OVA/TA coatings adhered firmly on five hydrophobic polymer materials using a two-step impregnation method and were highly hydrophilic and repellent to bacterial adhesion. Taking advantage of the reducing ability of OVA and TA, silver ions were reduced