Nghiên cứu ảnh hưởng trên hô hấp, tuần hoàn và các tác dụng không mong muốn khác trên 60 bệnh nhân được gây tê tủy sống bằng bupivacain + morphin để mổ và giảm đau sau mổ lấy thai. Kết quả nghiên cứu cho thấy gây tê tủy sống để mổ lấy thai bằng 8 mg bupivacain + 25 mcg fentanyl các tác dụng trên tuần hoàn, hô hấp người mẹ thương đương với gây tê tủy sống bằng 8 mg bupivacain + 100 mcg morphin, các tác dụng không mong muốn khác cũng tương đương nhau trừ tỷ lệ ngứa ở nhóm bupivacain + morphin cao hơn nhóm bupivacain + fentanyl. Cả 2 phương pháp đều không ảnh hưởng đến Apgar sơ sinh.Objectives: To compare the effect on respiration, on cardiovascular of the mother and other side effects on the mother and child of spinal anesthesia with, bupivacaine + morphine versus spinal anesthesia with bupivacaine + fentanyl for cesarean section. Method and subjects: A randomized clinical trial, 60 patients undergoing cesarean section under spinal anesthesia were allocated into two groups: BF group using 8 mg bupivacaine + 25 meg fentanyl
BM group used 8 mg bupivacaine + 100 meg morphine. Research parameters: On the mother: respiratory rate, heart rate, SpO2, and other side effects were recorded in the first 24h postoperation
the newborn was evaluated using the Apgar score. Results
On maternal
No difference in heart rate, mean arterial blood pressure, respiratory rate, SpO2 of patients in both study groups at all study time. Other side effects of BF and BM group were nausea, vomiting 13.3% versus 20%
itching was 13.3% versus 23.3%
chills were 13.3% versus 10%
No cases of respiratory distress in either study group. On the first minute Apgar score of BF group and BM group respectively were: 9.1 ± 0.2 vs. 9.2 ± 0.3
Apgar fifth minute of the two groups respectively were: 9.5 ± 0.4 vs. 9.4 ± 0.5. Conclusion: Spinal anesthesia for caesarean section with 8 mg bupivacaine + 25 meg fentanyl had effect In maternal respiratory, maternal eardiovasculary was equivalent to spinal anesthesia with 8mg bupivacaine + 100 mcg morphine, other side effects were similar exceptions the prurit was higher in the BM group than in the BF group (p <
0.05). Boft methods do not affected the Apgar score of neonatal.