Backgrouds: Retropentoneal tumor is a type of tumor that develops in the peritxineal cavity. In which neuroblastoma and renal papillae are the most common. Imaging diagnoisis takes an important role in the detection,diagnosis, foliow of tumors and so does Computer tomographic. Objectives: To determine the value of Computer tomographic In diagnosis of primary retroperitoneal neoplasms in children. Patients and Methods: 96 pediatric patients were diagnosed neuroblastoma (49 cases) and Wilms (47 cases) at the Children Hospital No.2 Ho Chi Minh city from August 2013 to September 2017. Study was designed with prospective analysis. Tools and means of study: CT images were taken by "CT Light Speed" machine with 8 probe ranges of GE incorporation, USA. Results: Most tumors are heterogeneous after contrast injection. The calcification rate in neuroblastoma (83.7%) was significantly higher than that in Wilms' tumor (17%). Necrotic tumors were high, accounting for 77.6% of neunsblastoma and 74.5% of Wilms' tumor. The incidence of hemorrtiage was higher in neuroblastoma (77.6%) than in Wilms' tumor (46.8%). The prevalence of vascular occlusion in BK neunablastoma group was significantly higher in the Wilms' tumor group (69.4% vs. 2.1%). Vascular pressure in neuroblastoma was 59.2% and In Wilms' tomor was 55.3%. Signs of tumors crossing the midline accounted for 57.1% of patients with neuroblastoma and 59.6% of patients Wilms' tumor. Conclusions: CT is valuable in the diagnosis of primary retroperitoneal neoplasms in children to dlstinguishe neuroblastoma with Wilms' tumor. Also, CT helps to choose appropriate therapy, and follow up after treatment as well.Nghiên cứu đặc điểm hình ảnh cắt lớp vi tính u sau phúc mạc trên 96 bệnh nhi, trong đó có 49 tường thợp u nguyên bào thần kinh và 47 trường hợp u nguyên bào thận tại bệnh viện Nhi đồng 2 từ 8/2013 đến 9/2017. Kết quả cho thấy hầu hết các u bắt thuốc không đồng nhất sau tiêm cản quang. Tỷ lệ vôi hóa trong u nguyên bào thần kinh là 83,7%, cao hơn so với u nguyên bào thận (17%). Tỷ lệ u xuất huyết trong u nguyên bào thần kinh là 77,6%, còn u nguyên bào thận là 46,8%. Tỷ lệ đè đẩy mạch máu trong u nguyên bào thần kinh là 59,2% và trong u nguyên bào thận là 55,3%. Dấu hiệu u vượt qua đường giữa chiếm 57,1%.