Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS.

• Tác giả: Marina Bouchè, Andrea Bracaglia, Chiara Cappelletti, Paolo D'Angelo, Chiara D'Ercole, Alberto Ferri, Lorenzo Giordani, Lucia Latella, Biliana Lozanoska-Ochser, Alberto Macone, Luca Madaro, Cristina Parisi, Daisy Proietti, Veronica Ruggieri, Silvia Scaricamazza, Cristiana Valle
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 54723

Tóm tắt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing progressive paralysis due to motor neuron degeneration with no curative therapy despite extensive biomedical research. One of the primary targets of ALS is skeletal muscle, which undergoes profound functional changes as the disease progresses. To better understand how altered innervation interferes with muscle homeostasis during disease progression, we generated a spatial transcriptomics dataset of skeletal muscle in the SOD1