Using the Ukrainian version of the Medical Outcomes Study Short Form, MOS SF-36 questionnaire for assessment of quality of life (QoL), a prospective analysis of the QoL of patients with bladder cancer who underwent radical surgery in the scope of radical cystectomy (group 1, 15 patients) and organ-preserving surgeries (bladder resection or transurethral resection, group 2, 40 patients) was conducted in the period from 2020 to 2022 at the Center for Urology and Urologic Oncology of the Feofania Clinical Hospital. The survey was conducted 1 week before radical surgery and 6 months after surgery. None of the studied patients had signs of recurrence or progression of bladder cancer during the postoperative survey. With identical QoL indicators before surgery, patients who underwent organ-preserving surgeries demonstrated significantly higher QoL indicators, such as physical, role, social, emotional functioning, and psychological health.