Quantitative beam optimization for radiotherapy of peripheral lung lesions: A pilot study in stereotactic body radiotherapy.

• Tác giả: Leslie Bell, Kai Ding, Reza Farjam, Russell K Hales, Sarah Han-Oh, Hamed Hooshangnejad, Jina Lee, Khinh Ranh Voong
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of applied clinical medical physics , 2025
• Bộ sưu tập: NCBI
• ID: 549095

Tóm tắt

 BACKGROUND: To quantify beam optimization for stereotactic body radiotherapy (SBRT) of peripheral lung lesions. METHOD: The new beam optimization approach was based on maximizing the therapeutic gain (TG) of the beam set by minimizing the average physical depth of the lesion with respect to the beam's eye view (BEV). The new approach was evaluated by replanning the 25 SBRT lesions retrospectively to assess if a better plan is achievable in all aspects. Difference in 25 Gy isodose line volume (IDLV RESULTS: Beam optimization achieved a better plan in all cases by lowering the depth of treatment with an average of % 20.03 ± 12.30 (3.66%-45.78%). As the depth of treatment decreases, the size of the plan also decreases. We observed a reduction of % 4.64 ± 4.55 (0.02%-21.58%, p <
  3.8 × 10 CONCLUSION: Physical depth of the lesion with respect to the BEV is inversely proportional to the TG of a beam-set and can be used as a robust and standard metric to select an appropriate beam-set for SBRT of the peripheral lung lesions. Further evaluation warrants the utility of such concept in routine clinical use.