NR4A1 deficiency promotes carotid plaque vulnerability by activating integrated stress response via targeting Bcat1.

• Tác giả: Zhaohua Cai, Haiping Chen, Long Chen, Ben He, Yijie Huang, Huanhuan Huo, Yangjing Jiang, Feng Liang, Min Liang, Zhitong Liu, Qin Shao, Yiping Shi, Xia Wang, Danrui Xiao, Jieyuan Xue, Guo Zhou, Fei Zhuang
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Cellular and molecular life sciences : CMLS , 2025
• Bộ sưu tập: NCBI
• ID: 549138

Tóm tắt

Rupture of vulnerable carotid atherosclerotic plaque is one of the leading causes of ischemic stroke. However, the mechanisms driving the transition from stable to vulnerable plaques have not yet been elucidated. NR4A1 is an orphan nuclear receptor that functions in various inflammatory diseases. To explore the role of NR4A1 in vulnerable plaque formation, we generated a vulnerable plaque mouse model by combining partial ligation of the left common carotid artery and left renal artery in ApoE