Adolescents aged 12-18 with social anxiety disorder (SAD) manifest various emotional and behavioral problems, among which non-suicidal self-injury (NSSI) requires urgent attention. Coping mechanisms for psychological distress significantly impact their vulnerability to NSSI. Understanding the heterogeneity of coping styles among adolescents with SAD can help identify those at high risk for NSSI. However, existing research provides little insight into this matter. This study aims to explore the latent profiles of coping styles in adolescents with SAD and analyze their association with NSSI behaviors. Two hundred and seventy-eight adolescents with SAD were assessed using the Cope-Styles Scale for Middle School Students and the Ottawa Self-Injury Inventor at the clinic. Latent profile analysis was used to analyze their coping styles. The binary logistic regression (using the three-step procedures implemented in the R3STEP auxiliary command) was used to explore sociodemographic predictors of latent coping profiles, such as gender, age, parental marital status, and family economic status. The BCH three-step procedures were employed to analyze differences in NSSI frequency among these profiles. Two profiles were identified, namely the high problem-focused coping group (48.20%) and the low problem-focused coping group (51.80%). Adolescents with SAD in the high problem-focused group had fewer NSSI behaviors than those in the low problem-focused group over the past month (χ