Effects of target coverage on local recurrence in stereotactic body radiotherapy for early-stage lung squamous cell carcinoma.

• Tác giả: Akio Hiwatashi, Nozomi Kita, Akane Matsuura, Akio Niimi, Masanari Niwa, Masanosuke Oguri, Dai Okazaki, Shuou Sudo, Seiya Takano, Taiki Takaoka, Natsuo Tomita, Akira Torii, Machiko Ukai
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.865 +Early cell division
• Thông tin xuất bản: Japan : Japanese journal of radiology , 2025
• Bộ sưu tập: NCBI
• ID: 549251

Tóm tắt

BACKGROUND AND PURPOSE: This study investigated effects of target coverage on local recurrence (LR) in stereotactic body radiotherapy (SBRT) for early-stage lung squamous cell carcinoma (SCC). MATERIALS AND METHODS: Patients with clinical stage IA1-IIA lung SCC treated with SBRT were included in the analysis. Doses of 48-52 Gy were prescribed to the isocenter of the planning target volume according to the tumor diameter. The primary endpoint was LR. To examine the independent effects of dosimetric factors on LR after adjustment for clinical factors, Fine-Gray model with death as a competing risk was used for evaluation. RESULTS: Among all 59 patients analyzed, the median follow-up was 42 months. The 3-year LR rate was 24.0%. Univariate analysis of clinical factors showed that biologically effective dose calculated with an α/β value of 10 (BED CONCLUSIONS: ITV coverage may be particularly important in SBRT for early-stage lung SCC.