Cross-sectional imaging, especially MR enterography (MRE) and intestinal US, plays an increasingly important role in the diagnosis and monitoring of Crohn disease. In this article, the authors share their approach to imaging Crohn disease, drawing on their clinical and research experience. They consider how to select the most appropriate modality for different clinical indications and discuss technical aspects to maximize diagnostic accuracy. The focus then shifts to how to use imaging to assess disease activity and treatment response in day-to-day clinical practice and the clinical potential of disease activity scores from MRE and intestinal US. The authors finish by discussing the benefits of intestinal US in ulcerative colitis.