Cascade Pd-Catalyzed Azide-Isocyanide Cross Coupling/Cyclization/Lactamization Reactions for the Synthesis of Tricyclic Guanidine-Containing Polyheterocycles.

• Tác giả: Zijie Gao, Lingfeng Luo, Xiaoming Ma, Jiawei Niu, Shenghu Yan, Qiang Zhang, Sai Zhang, Wei Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: United States : The Journal of organic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 54980

Tóm tắt

A one-pot synthesis of a tricyclic guanidine scaffold is developed. The azido-bearing [3 + 2] adducts are used for cascade azide-isocyanide cross-coupling/nucleophilic cyclization/lactamization to afford highly condensed polyheterocycles. A wide range of azido-containing [3 + 2] adducts and isocyanides are tolerated in the sequential reactions.