Chemoselective Functionalization of Tertiary C-H Bonds of Allylic Ethers: Enantioconvergent Access to sec,tert-Vicinal Diols.

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Tác giả: Renxu Cao, Yuqing Chen, Erjun Hao, K N Houk, Yunhe Jin, Yonghong Liu, Jing-Ran Shan, Lei Shi, Xin Wang, Zhixian Wu

Ngôn ngữ: eng

Ký hiệu phân loại: 636.0885 Animal husbandry

Thông tin xuất bản: Germany : Angewandte Chemie (International ed. in English) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 54985

While enantioenriched alcohols are highly significant in medicinal chemistry, total synthesis, and materials science, the stereoselective synthesis of tertiary alcohols with two adjacent stereocenters remains a formidable challenge. In this study, we present a dual catalysis approach utilizing photoredox and nickel catalysts to enable the unprecedented chemoselective functionalization of tertiary allylic C-H bonds in allyl ethers instead of cleaving the C-O bond. The resulting allyl-Ni intermediates can undergo coupling with various aldehydes, facilitating a novel enantioconvergent approach to access extensively functionalized homoallylic sec,tert-vicinal diols frameworks. This protocol exhibits nice tolerance towards functional groups, a broad scope of substrates, excellent diastereo- and enantioselectivity (up to 20:1 dr, 99% ee). Mechanistic studies suggested that allyl-NiII acts as the nucleophilic species in the coupling reaction with carbonyls.
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