New mouse model for inducible hACE2 expression enables to dissect SARS-CoV-2 pathology beyond the respiratory system.

• Tác giả: Dominik Arbon, Jana Balounova, Olha Fedosieieva, Federica Gambini, Juraj Labaj, Petr Nickl, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Jana Trylcova, Jan Weber, Vaclav Zatecka
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Mammalian genome : official journal of the International Mammalian Genome Society , 2025
• Bộ sưu tập: NCBI
• ID: 551398

Tóm tắt

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection is not limited to the respiratory tract as receptors, including the angiotensin-converting enzyme 2 (ACE2), are expressed across many tissues. This study employed a new conditional mouse model, Rosa26