Pithecellobium dulce Benth. commonly known in Mexico as "guamúchil", has been used to treat different diseases due to its pharmacological attributes. P. dulce arils are an important source of metabolites, with antioxidant and antihyperglycemic activities. Scarce studies have evaluated the antioxidant capacity, total phenolic content (TPC), and total anthocyanin content (TAC) in the red aril variety at different maturity stages, to our knowledge, no one has evaluated these properties in the white aril variety. The antihyperglycemic activity at different stages of ripening in P. dulce has not yet been reported. Also, its biosafety in human erythrocytes remains unexplored. This study assessed the in vitro antioxidant, antihyperglycemic, and haemolytic activities of red and white P. dulce aril hydroalcoholic extracts at different stages of ripening. The red mature aril (MRA) hydroalcoholic extracts presented the higher TPC (3103.2 ± 429.5 mgGAE·100 g