Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease.

• Tác giả: Kei Irie, Phillip Minar, Tomoyuki Mizuno, Nieko Punt, Jack Reifenberg, Abigail Samuels, Alexander A Vinks
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Clinical and translational science , 2025
• Bộ sưu tập: NCBI
• ID: 551597

Tóm tắt

The use of model-informed precision dosing to personalize infliximab has been shown to improve both the acquisition of concentration targets and clinical outcomes during maintenance. Current iterations of infliximab pharmacokinetic models include time-varying covariates of drug clearance, however, not accounting for the expected improvements in the covariates can lead to indiscriminate use of higher infliximab doses and imprecise drug exposure. The aim was to identify changes in the four biomarkers associated with infliximab clearance (Xiong et al. model) and determine if integration of these dynamic changes would improve model performance during induction and early maintenance. We analyzed two cohorts of children receiving infliximab for Crohn's Disease. The E