Monoamine oxidase inhibitors are promising drug targets for many neurological diseases such as depression, Alzheimer's disease, and Parkinson's disease. The current study developed new hybrid compounds by merging phenyl piperazines, and 2,4-thiazolidinedione moieties based on their reported MAO inhibitory activities. The newly synthesized derivatives were screened for their MAOs inhibitory activity using in-vitro fluorometric assay. Most newly synthesized compounds elicited strong inhibitory activity against both hMAO isozymes. Hybrids 4a and 4c were the most potent hMAO-A inhibitors with IC