Investigating the fate of Zirconium-89 labelled antibody in cynomolgus macaques.

• Tác giả: Masaru Akehi, Takahiro Higuchi, Sadaaki Kimura, Eiji Matsuura, Sosuke Miyoshi, Yoshihiro Murakami, Akihiro Noda, Kazuhiko Ochiai, Takanori Sasaki, Masami Watanabe
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.189352 Engineering mechanics and materials
• Thông tin xuất bản: United States : Nuclear medicine and biology , 2025
• Bộ sưu tập: NCBI
• ID: 551685

Tóm tắt

BACKGROUND: Preclinical pharmacokinetic studies of therapeutic antibodies in non-human primates are desired because of the difficulty in extrapolating ADME data from animal models to humans. We evaluated the pharmacokinetics of METHODS: Selected IgG was conjugated to desferrioxamine (DFO), labelled with RESULTS: After CONCLUSION: In the non-human primate cynomolgus macaque,