Genomic and transcriptomic analyses unveil the genetic basis of green shank trait in small white-feather chickens.

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Tác giả: Bolin Cai, Danfeng Cai, Xiaodian Cai, Shaofen Kong, Duo Lin, Qinghua Nie, Yuanrong Xian, Xin Yang, Zhen Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: England : Poultry science , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 551753

Small white-feather chickens (SWFC) have become popular as a hybrid strain recently. Shank color is a notable economic trait in this strain. Despite numerous studies on the green shank trait from both physiological and genetic perspectives, research focusing specifically on the green shank trait in hybrid chickens (HC) remains limited. In this study, to investigate the genetic mechanisms and molecular basis of the green shank trait in HC, we created a population by intercrossing white-feathered and yellow-feathered broilers, both with yellow shanks. Physiological analysis confirmed that melanin deposition in the shank dermis is the primary cause of the green shank trait in HC. By combining genome-wide association studies (GWAS) and population genomics analysis, the 83.20-85.68 Mb region on the Z chromosome was identified as a candidate region for the green shank trait in HC. Transcriptome sequencing revealed differentially expressed genes (DEGs) between green shank and yellow shank individuals, with MTAP and CDKN1A identified as candidate genes in the genomic region associated with the green shank trait. Notably, the green shank trait includes a light green phenotype. Our study is the first to identify genes associated with different color depths of the green shank. The candidate genes influence both the biosynthesis and deposition of pigments.
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