Aluminum, a non-essential metal, identified as potentially toxic to organisms, is increasingly released and accumulated into the aquatic ecosystems as a result of human activities. However, only a few data are available regarding its action in aquatic vertebrates during their early stages of development. In order to further investigate the toxicity mechanisms induced by this metal, we used a relevant model in ecotoxicology Xenopus laevis. Oocytes and embryos were exposed to aluminum sulfate (Al