In front of the potential risks of agricultural production in Vietnam in general and the Mekong Delta in particular, the contribution of high-tech agriculture and the role of actors in all economic sectors, especially is the private sector is very important. However, public internal constraints with external challenges are still a barrier to the private sector's expansion of investment in high-tech agriculture in the Mekong Delta. The paper examines issues related to investment in high-tech agriculture of the private sector and proposes the direction of private sector development in this area in the future.