Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain.

• Tác giả: Zihui Chen, Yuxuan Gao, Lukuan Hou, Wenli Li, Shuyao Wang, Xue Yang, Yuanhang Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.322 Drugs derived from bryophytes
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 552022

Tóm tắt

Heterologous expression of a nonconventional terpene biosynthetic gene cluster from the deepsea-derived Streptomyces amphotericinicus DS22-01 led to the production of a novel cyclic diterpene, ostamycin A (1). Anti-influenza A virus activity evaluation revealed that compound 1 showed significant activity with an IC