The international exchange of physician assistant (PA) education between the Medical University of South Carolina (MUSC) in the United States and Inholland University in the Netherlands, established in 2013, aims to enhance global awareness, cultural sensitivity, and professional development among PA students. This exchange program, which transitioned to a virtual format during the COVID-19 pandemic and resumed in-person exchanges in 2023, allows participants to explore similarities and differences in medical education, healthcare systems, and professional practices between the two countries. Despite varying educational pathways and healthcare models, the role of PAs in both countries shows remarkable similarities, including shared responsibilities in patient care and clinical practice flexibility. The program, which includes lectures, clinical shadowing, and cultural immersion, fosters a deeper understanding of global healthcare and promotes introspection among participants regarding their own healthcare systems. Student reflections highlight the transformative impact of the exchange on their cultural humility and global perspective. Future plans for the program include enhanced virtual interactions to strengthen cross-cultural connections and further explore healthcare topics. This exchange serves as a model for fostering international collaboration and broadening the global PA community.