Effectiveness of Photobiomodulation (low-level laser therapy) on treatment of oral mucositis (OM) induced by chemoradiotherapy in head and neck cancer patients.

• Tác giả: Pantea Amiri, Shadi Barati, Reza Fekrazad, Safa Motevasseli, Hamid Saeidi Saedi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 344.073 Education by level of government
• Thông tin xuất bản: Switzerland : Journal of photochemistry and photobiology. B, Biology , 2025
• Bộ sưu tập: NCBI
• ID: 552296

Tóm tắt

 PURPOSE: Mucositis is a common and debilitating side effect of cancer treatment, causing significant pain and discomfort. This study aimed to evaluate the effectiveness of Photobiomodulation in treating mucositis induced by chemoradiotherapy in cancer patients. METHODS: This randomized, single-blind clinical trial involved 36 patients with grade 3-4 oral mucositis. The test group (n = 18) received diode portable laser therapy (810 nm wavelength, 200 mW power, 6 J/cm RESULTS: Pain scores in the laser group decreased significantly over time (P <
  0.05). Patients in the laser group reported better quality of life and reduced oral discomfort compared to the control group (P <
  0.05). The severity of mucositis significantly decreased in the laser group within the first week (P <
  0.05), though no significant difference was observed at one month (P = 0.158). CONCLUSION: The study demonstrates that Photobiomodulation is a more effective and efficient method for reducing pain, tingling, and improving quality of life in both the short and long term. It also reduces the severity of oral mucositis in the short term for patients with head and neck cancer undergoing chemoradiotherapy.