BACKGROUND: This study compared healthcare resource utilization (HCRU) and cost among patients treated for pit viper envenomation with Fab or F(ab') RESEARCH DESIGN AND METHODS: Patients administered Fab or F(ab') RESULTS: In total, 242 and 98 patients receiving Fab and F(ab') CONCLUSIONS: Patients administered Fab had higher post-index total, inpatient, and inpatient pharmacy costs than patients administered F(ab')