Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease that is diagnosed in women twice as often as in men, especially in groups of family cases and at the age of up to 35 years. Among patients diagnosed with MS, there are many young and middle-aged women who are planning a pregnancy in the future and want to protect themselves from unwanted pregnancy at the present time. Also, for patients with MS, the importance of reducing the frequency of abortions is obvious. The question arises - what drugs are safe, convenient and effective for this group of patients. Moreover, one of the modern hypotheses of treatment in relation to reducing relapses and progression of MS is the use of estrogen. Therefore, the strategy of choice may be the use of estrogen-containing oral contraceptives as means that provide effective protection against pregnancy and at the same time, possibly, affect the course of the underlying disease in a positive way.