OBJECTIVE: To conduct a comparative analysis of EEG spectral power indicators in patients with alcoholism with- or without exogenous organic brain disease. MATERIAL AND METHODS: An analysis of 119 EEG of patients with alcohol dependence was carried out. The presence of exogenous organic brain disease in patients was assessed retrospectively (through anamnesis). The EEG signals received from 16 electrodes were first divided into 3 frequency spectra (i.e. theta, alpha and beta), then the values of absolute spectral power were calculated, and then they were reordered, combined and topographically transferred to a spectral map. Data analysis was carried out in 5 different ways: electrode analysis, analysis based on cortical regions, lateralization, antero-posterior locus and throughout the whole cortex. RESULTS: In the group of alcohol-dependent patients with comorbid exogenous organic brain damage, significantly ( CONCLUSION: The results clearly indicate that the presence of exogenous organic brain damage in patients with alcohol dependence is accompanied by a change in the spectral power of the EEG mainly in the alpha frequency range.