[The experience of diagnosing Alzheimer's disease based on the study of cerebrospinal fluid biomarkers].

• Tác giả: A G Burmak, E Yu Fedotova, S N Illarioshkin, K V Nevzorova, A A Shabalina, Y A Shpilyukova
• Ngôn ngữ: eng
• Thông tin xuất bản: Russia (Federation) : Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova , 2025
• Bộ sưu tập: NCBI
• ID: 55293

Tóm tắt

 OBJECTIVE: To evaluate the frequency of Alzheimer's disease (AD) confirmed by cerebrospinal fluid (CSF) biomarkers in a cohort of patients with classical (amnesic) and atypical phenotypes of this disease. MATERIAL AND METHODS: The study included 63 patients (24 men and 39 women
  median age 65 years [60
  71]). All patients were divided into 3 groups according to the phenotype: a classic amnesic phenotype ( RESULTS: A decreased level of CSF Aβ1-42 in combination with an increased level of CONCLUSION: The high frequency of AD CSF biomarkers in both the classical (amnesic) and atypical phenotypes is shown. This indicates the need to expand the use of AD CSF biomarkers for a more reliable assessment of the prevalence of AD In Russia.