After the presentation of the basic implications of start-up innovation, entrepreneurship ecosystem, the characteristics of start-up innovation, the article analyzes some lessons from some countries on policy, promote entrepreneurship innovation. Analyze the current status of policies to promote Vietnam's entrepreneurial innovation, about inadequacies and challenges. Next proposed some solutions to promote start-up innovation activities, especially need to build a set of evaluation criteria to promote the start-up innovation and think about a bearing solution breakthroughs in exploiting and trading intellectual sources at universities.