Development of a Thioetherification of Heteroarene Electrophiles with Broad Scope via a Proton Transfer Dual Ionization Mechanism.

• Tác giả: Anna V Bay, Maike Eckhoff, Jeremy J Henle, Rodger F Henry, Jessica N Hoskins, Shashank Shekhar, Matthew S Sigman, Rafal Swiatowiec, Amanda L Wall, Cassie Yang, Yong Zhou, Christian R Zwick
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.762 Diseases of ocular neuromuscular mechanism
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 55384

Tóm tắt

Sulfur-derived functional groups represent prevalent motifs in highly sought-after small molecules, such as active pharmaceutical ingredients (APIs). Thioethers are one such example, being commonly encountered in APIs, prodrugs, and as valuable synthetic "linchpins" to access an array of sulfur-derived functional groups. While nucleophilic aromatic substitution (S