Azasilanes have excellent bioactivities
however, asymmetric synthesis of azasilinan-6-one with a substitution at the second potion has been investigated very little. In this paper, (R)-2-[3-(methoxymethoxy)propyl]-3,3-diphenyl-I-tosyl-I,3-azasilinan-6-one was successfully synthesized. The chiral center of silylsulfinamide was prepared by the addition of silyl lithium to (R)-Davis' chiral sulfinimine. Cyc1ization of delta-amino carboxylic acid gave 1,3-azasilinan-6-one that can be an important product to synthesize 2-substituted 1,3-azasilinan rings. Structures of all new compounds were confirmed, by IR, 1H and 13C-NMR, along with the exact mass.