5-( 4-Bromophenyloxymethyl)-1,3,4-oxadiazol-2-thiole (3a) and 5-(4 -methylphenyloxymethyl)-1,3,4-oxadiazol-2-thiole (3b) were synthesized starting from 4-bromophenol and 4-methylphenol (p-crezol), respectively. The 5-aryl-oxymethyl-1,3,4-oxadiazole-2-thiole (3a, b) were treated with N-aryl-2-chloro-acetarnides to give six corresponding new N-aryl-[(5-aryloxymethyl-1,3,4-oxadiazol-2-yl)sulfanyl] acetamides (4al-3, 4b1-3). The structures of the compounds were confirmed by IR, 1H-NMR and MS spectral data. At concentrations up to 0.2 percent, the acetamide compounds (4al-3, 4b1-3) exhibited weak antibacterial capacity against Escherichia coli and Bacillus subtilis.