[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].

• Tác giả: S A Galkin, S A Ivanova, E G Kornetova, I A Mednova, D Z Paderina, V V Tiguntsev
• Ngôn ngữ: eng
• Ký hiệu phân loại: 286.136 *American Baptist Association
• Thông tin xuất bản: Russia (Federation) : Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova , 2025
• Bộ sưu tập: NCBI
• ID: 55456

Tóm tắt

OBJECTIVE: To study the associations of MATERIAL AND METHODS: One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three RESULTS: Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r CONCLUSION: Genetic variants rs12029454, rs10494366 and rs12143842 of the