OBJECTIVES: As the need for efficient and minimally invasive strategies for the aesthetic management of hypomineralised and demineralised enamel lesions is critical, this systematic review aimed to assess the postoperative stability of aesthetic outcomes achieved after resin infiltration in permanent incisors, canines and premolars. DATA/SOURCES: This systematic review was conducted according to the PRISMA guidelines. The search strategy was based on PICO reporting system. Publications (up to September 2024) investigating the postoperative stability of aesthetic outcomes following resin infiltration of hypomineralised and demineralised enamel lesions were identified in a systematic search using MEDLINE/PubMed, Scopus and DOSS electronic databases. Only clinical studies were included. Additionally, science mapping analysis and quality assessment of selected full-text articles were performed using keyword co-occurrence networking on VOSviewer and the NIH Before-After Cohort Study assessment tool or Rob 2 tool, respectively. STUDY SELECTION: From an initial total of 664 studies, 15 were included in the final analysis, based on inclusion/exclusion criteria. A total number of 1518 teeth from 374 patients were included. All studies showed that the outcome obtained after resin infiltration of hypomineralised and demineralised lesions remained aesthetically stable over short, medium and long periods. However, this review highlighted that most of these studies: i/ exclusively focused on a single criterion, colourimetry, ii/ were restricted to short follow-up periods, and iii/ displayed a moderate risk of bias. CONCLUSIONS: This systematic literature review highlights good stability of postoperative aesthetic outcomes following resin infiltration of hypomineralised and demineralised enamel lesions in permanent teeth. However, additional clinical studies are needed in order to achieve a higher level of scientific evidence regarding the longevity of this therapeutic intervention.