Objective: The study of independent predictors of acute ischemic stroke (IS) in the oldest-old (>
75 years) with the elderly (from 60-75 years), Subject and method: Data are for 308 consecutive IS patients aged >
60 years (138 aged >
75years) admitted to an stroke unit of Phu Tho hospital from (2014-2017). Demographics, prestroke disability (modified Rankin Scale >
3) and comorbidties, IS etiology and subtype, NIH Stroke Scale (NIHSS) score, clinical and laboratory admission parameters and medical complications were prospectively registerd. Independent predictors of inhospital death, incident disability, length stay, dischage without rehabilitation, and no direct discharge home were identified by multiple logistic regression. Risk profiles before and after age 75 were compared. Result: Poor outcomes were more frequent in the oldest-old (>
75 years) compared to the younger patients (<
75 years). NIHSS score, elinical parameters of IS severity (need for oxygen, indwelling catheter, or nasogastric tube), incidents disability, and medical complications predicted most of the study outcomes in both age groups. After age 75, IS etiolofy and subtype proved additional independent determinants for most outcomes along with age, sex, and prestroke functional and health status. Conclusions: Identified by multiple logistic regression were: independent predictors prestroke and first threedays in the hospital of acute ischemic stroke in the oldest-old (>
75 years) were dependent, mechanical ventilation and pneumonia
the patients (<
75 years) was atrial fibrillation were Poor outcomes and death when discharge.