Design, synthesis, antimalarial activity, and in-silico studies of new benzimidazole/pyridine hybrids as dihydrofolate reductase inhibitors.

• Tác giả: Tahani Mazyad Almutairi, Mariam E Amin, Ahmed A El-Rashedy, Phoebe F Lamie, Fatma A M Mohamed, Martha M Morcoss, Jakline Nelson Saddik, Bahaa G M Youssif
• Ngôn ngữ: eng
• Ký hiệu phân loại: 747.73 Studies
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 55586

Tóm tắt

Molecular hybridization of substituted 2-phenylbenzimidazole and pyridine moieties afforded a new series of antimalarial targeting compounds 5a-l. They were assessed against both chloroquine resistant -W2 (CR-W2) and chloroquine sensitive-D6 (CS-D6) strains of P. falciparum. Artemisinin and chloroquine were used as standards drugs. Results revealed that compounds 5e, 5j, 5k and 5l were the most effective against CS-D6 P. falciparum strain with IC