NPMl and FLT3-ITD mutations have the important role in prognosis acute myelogenous leukemia with normal cytogenetics. Objects: (1) Analyse the rate of NPM1 and FLT3-ITD mutations in acute myelogenous leukemia with normal cytogenetics, (2) Study the relationship between NPM1 and FLT3-ITD muations with response of induction therapy. Patients and method: 100 patients with acute myelogenous leukemia (AML) were studied. Cytogenetic analysis and PeR testing to detect NPM1, FLT3-ITD was done before were taken the induction chemotherapy and the complete remission was estimated. Results: The rate of normal cytogenetics was 55 percent, the rate of NPM1 and FLT3 in acute myelogenous leukemia with normal cytogenetics was 36,3 percent and 27,3 percent. The NPM1(+)/FLT3-ITD(-) group had higher complete remission (100 percent). The neutrophilia after induction was lowest in NPM1(-)/FLT3-ITD(+) group (0,83 percent 2,04 G/I) and rate of uninfections was highest in NPM1(+)/FLT3ITD(-) group (19,2 percent.) Conclusion: NPMl mutation was better risk and FLT3-ITD was poor risk in acute myelogenous leukemia with normal cytogenetics.