Objectives: To determine the safety and effectiveness of dehydrated scleral patch grafts in Ahmed valve implantation. Patients and methods: A prospective, clonical trial study was conducted on patients including adults and children who were implanted Ahmed glaucoma valves with the use of the dehydrated scleral patch grafts to cover the tubes in Ho Chi Minh city Eye Hospital in 2009-2010. Timefor absorption and complications of scleral graft such as dellen formation, graft rejection, graft-related infection, and graft thinning or tube erosion were recorded. Results: Seventy- six eyes of children and adults were received AVG and covered silicon tube by dehydrated scleral patch grafts. The mean follow-up time was 14.84 + or - 6.21 months (6-29 months). It took 7.29 + or - 1.44 months for the grafts to be absorbed completely. Besides one case of corneal dellen, no other complications such as graft rejection, graft infection, or tube erosion was observed. Conclusions: Dehydrated scleral patch grafts appear to be well tolerated and can be used as tube coverage in the implanted glaucoma drainage devices.