Objectives: Evaluate the results of operation (Laparoscopic and open methods) for submucosa tumor of stomach at Hanoi Medical University Hospital. Patients and methods: Cross-sectional study on the patients with submucosa tumor of stomach who underwent surgery at Hanoi Medical University Hospital from 8/2008 - 8/2013. Results: Total 56 patients, the mean age of the patients was 49.95 + or - 14.5 (range 14-79), the patients with labor age rate 76.8 percent, male 29 and female 27. Laparoscopic method for 26 patients (46.4 percent), open method for 30 patients (53.6 percent). The good results for all of the patients, nobody with dangerous complication during and postoperation.