My Yen commune is located in South - West mountainous area of Dai Tu district, Thai Nguyen province, 10 km far from the district center, the total land area of 3392.60 ha with almost upland and remote area, agriculture is main production activities. Assess the situation and propose solutions to improve the efficiency of sustainable land use for agricultural production in My Yen commune, Dai Tu district, Thai Nguyen province has important implications for the selection of the type of suitable land use and increasing efficiency of sustainable land use. The research results show that this commune has 6 different types of land use (LUT), which brings various types of economic efficiency: rice (LUT) - annual crop, 2 rice - annual crop, this is a potential LUT that can bring effective opportunity for this area, especilally vegetable crop. This result is useful approach for selecting effective LUT to other areas.