Transcatheter aortic valve implantation is an alternative to conventional aortic valve replacement for patients at high surgical risk, with favorable procedural outcomes. Since 2002, more than 20,000 transcatheter aortic valve procedures have been performed worldwide. In the current 2 cases, the authors report for the first time in Vietnam, the transcatheter aortic valve implantation for the treatment of the severe aortic stenosis.