Research was carried out on 60 intravenous anesthesia patients randomly divided into 2 groups with 30 patients in each one in Anesthesiology in National Institute of Burns from January, 2012 to January, 2013. Group I was site effect controlled target concentration propofol intravenous anesthesia group and group II was manually adjusted propofol intravenous anesthesia group. The authors found: 1. The average propofol dose (mg/kg) for induction in the group I was lower than the group 1/ (1.83 mg/kg vs. 2 mg/kg), but induction duration in the group I was longer than the group 1/ (91.50s vs. 76.43s), so hemodynamic and respiratory parameters in the group I were more stable and adjusted more easily than the group II. Both groups maintained the anesthesia depth s 1 on the OAA/S score. However, anesthesia quality and the stability of patients in the group I were better than the group II, expressed on PRST score (1.65 in the group I and 2.73 in the group II. The dose adjustment times in the group I was fewer than the group II (0.80 times/h vs. 1.76 times/h). The recovery time of patients in the group I was longer than the group II (17.27 minutes vs. 15.90 minutes). 2. The unwanted effects were within limit, pulses and non invasive blood pressure in the group I less changed than in the group II and the anesthesia depth in the group I was more stable than in group II, the movements in surgery in the group I was fewer than in group II. The authors didn't see the severe side effects in anesthesia in both groups (cardiac affest, respiratory failure...).