The Inflammatory Palmoplantar Hyperkeratosis Syndrome was discovered in Ba To district, Quang Ngai province in 2011 and 2012. So far, the causes and related factors have not been detennined. This study was conducted to contribute to reduce morbidity and improve health conditions. The intervention model pre-post evaluation was conducted from May 2012 to June 2012. The interventions included measures of environmental hygiene
disinfectants, insecticides
free supply of rice, vitamins and nutritional products
health education and communication. Monitoring of disease progression, and tests of SGOT, SGPT, GGT, Protein, Albumin, and vitamin B3 in the blood was conducted before and after the intervention. This study showed positive results, reducing the symptoms of the disease, the rate of high level of SGOT from 83.6 percent to 36.9 percent, SGPT from 45.5 percent to 5.3 percent , and GGT from 54.0 percent to 47.7 percent, the rate of nonnallevel of Protein and Albumin, and level of vitamin B3 also increased significantly.