VOx/SBA-15 catalysts with different vanadium loading have been prepared by incipient wetness impregnation of SBA-15 with required solution of acetyl axetonate. The obtained samples were characterised by N2-desorption, XRD, TEM, H2-TPR, NH3-TPD, UV-Vis and also were tested for the oxidative dehydrogenation of n-butane. The experimental results showed that VOx/SBA-15 catalysts have a good activity for the studied reaction. The good performance can be attributed to the good dispersion of V species and the properties of the pore structure.