Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.

• Tác giả: Ahmadullah Ansari, Eddy Arnold, Xiang Chi, Xufang Deng, Alexandra Ford, Prakash Jadhav, Kan Li, Xueying Liang, Francesc Xavier Ruiz, Bin Tan, Haozhou Tan, Jun Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 303.623 Riots
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 55790

Tóm tắt

The ever-evolving SARS-CoV-2 variants necessitate the development of additional oral antivirals. This study presents the systematic design of quinoline-containing SARS-CoV-2 papain-like protease (PL