The objective of this study investigated the relationship between H. pylori infection, socioeconomic status, adult household crowding, marital and lifestyle. Patiens and methods: Cross sectional study including 418 patients with infected and uninfected H. pylori at gasto intestinal clinic of general center An Giang hospital from 01/2011 to 06/2011. Results: H pylori infection accounted for 55 percent among 418 subjects with different gastro-intestinal diseases. After using univariate analysis, there are 12 variable were statistically significant: gender, number of family members, marital status, house space, peptic ulcer history in the past, oral disease history, drinking alcohol, smoking, eating red peppers, source of drinking water, pet owner, latrine type. On analyzing multivariate regression logistic, only 4 variables: marital status, number of family members, peptic ulcer history were independent risk factors for H pylori infection adjusted OR (IC 95 percent): 1.78 (1.02-3.41)
1.58(1.0 1-2.47)
1.57(1.02-2.51), respectively]. Source of drinking water are related to infection H pylori, especially drinking river water without boiling was independent risk factor for H pylori infection [adjusted OR= 1.59, IC 95 percent (1.01-2.53)]. Conclusion: Marital status, number of family members, drinking river water without boiling, peptic ulcer history in the past were independent risk factors for H pylori infection. The results support a theory of person to person transmission and the role of sociodemographic for H pylori infection.