Studying on relation between serum beta2-microglobulin concentration and some features of 326 patients diagnosed as chronic renal failure treating with maintenance hemodialysis, the results show that 100 percent patients with high serum beta2-microglobulin, average beta2-microglobulin of patients was 64.7 + or - 21.1 mg/l, which was higher significantly than that of control group (1.88 + or - 0.68 mg/l), p 0.001. There was a close positive correlation between serum beta2-microglobulin and during of hemodialysis, r